Jonathon Root is an actor who opened and subsequently closed "Avenue Q" at Wynn. He is back in New York performing on Broadway. He made some interesting observations about Wynn's theater in his blog. Here is an excerpt and link to it.
"...The Broadway audiences are spectacular! Don't get me wrong, the
Vegas audiences could be great, but it was very hit-or-miss. One
night we would have a couple hundred people in the house and the
next night there would be a thousand! There was no consistency, no
way to predict how the house would react. This is a comedy. It
thrives off of audience response. That was tough to work around in
Vegas. On Broadway, every show is raucous. The Golden Theatre just
rocks with laughter. Which is another thing: something about the
design of the theatre at the Wynn made it so that the performers on
stage couldn't hear the audience reactions well. People would talk
to me after the show and say, "Wow, did you hear that reaction when
you said blah blah blah?" and I would respond, "Actually, no. No, I
didn't hear it." Something about its cavernous design limited the
audience sound coming up to the stage. In complete contrast, the
Golden Theatre is like a shotgun funnel. All sounds from the
audience shoot right down the lane and connects with you on stage.
THAT, my friends, is a Broadway Theatre. A truly give-and-take
experience where I could hear every chuckle and outright explosive
laughter from the audience. Oh, and did I mention how nice it is to
have a FULL HOUSE?..."